Studies of hermeneutics have rarely dealt with eighteenth-century British thought, yet during this period debates over the interpretation of texts plagued and invigorated religious, intellectual, and political life in England. This important book is the first to deal with hermeneutical issues in British scriptural, legal, historical, political, and literary interpretation. Examining the work of Swift, Locke, Toland, Bolingbroke, Hume, Reid, Blackstone, and Burke, Joel C. Weinsheimer discusses common philosophical problems of understanding, concentrating especially on their theories about the (...) application of taste to discern interpretive truth. Weinsheimer's approach is primarily philosophical. In each area of hermeneutic endeavor, he asks such questions as why it is necessary to interpret, what it means to interpret, what does not need interpreting, what constitutes the signs of right understanding, and what accounts for the multiplicity of interpretations. He concludes that hermneutics in eighteenth-century England became the site of a contest and possible reconciliation between reason and history. Driven by the need to escape rationalist formalism as well as an opposite though equally sterile antiquarianism, interpretation offered a new way of thinking about truth, as belonging to reason and history together. (shrink)

Entirely faithful to Boethius' Latin; Relihan's translation makes the philosophy of the Consolation intelligible to readers; it gives equal weight to the poetry--in fact, Relihan's metrical translation of Boethius' _metro_ are themselves contributions of the first moment to Boethian studies. Boethius finally has a translator equal to his prodigious talents and his manifold vision. --Joseph Pucci, Brown University.

The formation of a highly condensed chromosome structure (heterochromatin) in a region of a eukaryotic chromosome can inactivate the genes within that region. Genetic studies using the fruitfly Drosophila melanogaster have identified several essential genes which influence the formation of heterochromatin. My purpose in this review is to summarize some recent work on the genetics of heterochromatin assembly in Drosophila and a recent model for how chromosomal proteins may interact to form a heterochromatic structure.

The Roman philosopher Boethius is best known for the _Consolation of Philosophy_, one of the most frequently cited texts in medieval literature. In the _Consolation_, an unnamed Boethius sits in prison awaiting execution when his muse Philosophy appears to him. Her offer to teach him who he truly is and to lead him to his heavenly home becomes a debate about how to come to terms with evil, freedom, and providence. The conventional reading of the _Consolation_ is that it is (...) a defense of pagan philosophy; nevertheless, many readers who accept this basic argument find that the ending is ambiguous and that Philosophy has not, finally, given the prisoner the comfort she had promised. In _The Prisoner's Philosophy_, Joel C. Relihan delivers a genuinely new reading of the _Consolation_. He argues that it is a Christian work dramatizing not the truths of philosophy as a whole, but the limits of pagan philosophy in particular. He views it as one of a number of literary experiments of late antiquity, taking its place alongside Augustine's _Confessions_ and _Soliloquies_ as a spiritual meditation, as an attempt by Boethius to speak objectively about the life of the mind and its relation to God. Relihan discerns three fundamental stories intertwined in the _Consolation_: an ironic retelling of Plato's _Crito,_ an adaptation of Lucian's _Jupiter Confutatus,_ and a sober reduction of _Job_ to a quiet dialogue in which the wounded innocent ultimately learns wisdom in silence. Relihan's claim that Boethius's text was written as a Menippean satire does not rest merely on identifying a mixture of disparate literary influences on the text, or on the combination of verse and prose or of fantasy and morality. More important, Relihan argues, Boethius deliberately dramatizes the act of writing about systematic knowledge in a way that calls into question the value of that knowledge. Philosophy's attempt to lead an exile to God's heaven is rejected; the exile comes to accept the value of the phenomenal world, and theology replaces philosophy to explain the place of human beings in the order of the world. Boethius Christianizes the genre of Menippean satire, and his _Consolation_ is a work about humility and prayer. _“Acknowledging that the _Consolation of Philosophy_ is ‘over-familiar and under-read,’ Joel Relihan puts to the side old bromides about the work and instead pays careful attention to the narrative Boethius constructs, grounding his readings in the contexts the work cultivates, especially its Menippean elements. The result is perhaps the first satisfying reading of the _Consolation_ to be produced, a satisfaction felt also in the ways Relihan mirrors Boethius himself in the thoroughness of his scholarship and the elegance of his exposition. No one who studies Boethius will be able to ignore this book.“ — Joseph Pucci, Brown University _ "Anyone who has been fascinated, intrigued, or perhaps puzzled by the meaning, structure, or argument of Boethius's _Consolation of Philosophy_ will find Joel Relihan's new book a welcome addition to the study of this core text of the early medieval world whose influence extends to the present time. Relihan's study is a tour de force that belongs in the library of all those who appreciate Boethius's depth and subtlety. Fortune's wheel has indeed turned in the favor of those who wish to explore with Relihan the intricacies and brilliance of the _Consolation_." —_Fr. John Fortin, O.S.B., Saint Anselm College _. (shrink)

Eukaryotes organize certain chromosomal intervals into domains capable of si lencing most genes. Examples of silencing domains include the HML/HMR loci and subtelomeric chromatin in yeast, the Barr body X chromosome in mammals, and the pericentric heterochromatin of Drosophila. Silencing chromatin is often correlated with more regularized nucleosomal array than that found in active chromatin, and transcriptional activators appear to be missing from their target sites in silent chromatin. In Drosophila, gene silencing by heterochromatin is often variegated, indicating that a (...) gene may escape silencing in some cells. In a recent study, Ahmad and Henikoff(1) show that a yeast activator can compete successfully with Drosophila heterochromatic silencing factors for target sites in DNA. This competition, together with developmental change in the stability of heterochromatin itself, decides the transcriptional state for a gene subject to heterochromatin repression. BioEssays 23:767–771, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

Most tissues contain cells capable of the self‐renewal and differentiation necessary to maintain tissue and organ integrity. These somatic stem cells are generally thought to have limited developmental potential. The mechanisms that restrict cell fate decisions in somatic stem cells are only now being understood. This understanding will be important in the clinical exploitation of adult stem cells in tissue repair and replacement. Experiments performed over fifty years ago in Drosophila showed that developmental restriction could be relaxed in the proliferating (...) larval cells that are destined to form the adult fly integument. This phenomenon, called transdetermination, can serve as a model for mechanisms of stem‐cell commitment. A recent publication1 sheds new light on the mechanism of transdetermination by demonstrating that loss of homeotic gene silencing leads to increased frequency of transdetermination. In addition, the authors link a specific signaling pathway induced by tissue regeneration to the relaxation of homeotic gene silencing. The data identify key mechanisms that control developmental homeostasis and cell fate restriction that could be manipulated to make somatic stem‐cell engineering possible. BioEssays 28: 574–577, 2006. © 2006 Wiley Periodicals, Inc. (shrink)

So the modern editions print the opening words of the work more popularly known as the Caesares. The Symposium begins with what I consider to be a playful encounter between the narrator and his interlocutor, in which the latter's expectations of seriousness in the myth which is to follow are frustrated. This playfulness has not been appreciated by Julian's commentators. I suggest that we have here a concealed trimeter which figures largely in the dynamics of this dialogue : γελοον οδν (...) σδ τερπνν οδ' γ. (shrink)

So the modern editions print the opening words of the work more popularly known as the Caesares. The Symposium begins with what I consider to be a playful encounter between the narrator and his interlocutor, in which the latter's expectations of seriousness in the myth which is to follow are frustrated. This playfulness has not been appreciated by Julian's commentators. I suggest that we have here a concealed trimeter which figures largely in the dynamics of this dialogue :γελο⋯ον οὐδ⋯ν σὐδ⋯ (...) τερπν⋯ν οἶδ' ⋯γώ. (shrink)

Compassion is a prosocial motivation that is critical to the development and survival of the human species. Cultivating compassion involves developing deep wisdom, insight, and understanding into the nature and causes of human suffering; and wisdom and commitment to take positive action to alleviate suffering. This perspective piece discusses how compassion relates to the context of modern technology, which has developed at a rapid pace in recent decades. While advances in digital technology build on humankind’s vast capacity to develop practical (...) tools that promise to enrich our lives and improve our social connections, in reality the effects are often far from benign. The motives underlying the development of many contemporary digital platforms seem rooted in competitiveness and capitalism; while modern social media and online platforms are having a profound and pervasive impact on the mental health and wellbeing of humans around the globe. Nonetheless, digital technology holds considerable potential to promote compassionate insight, wisdom, and prosocial behavior. We reflect on the current state of technology within human society and examine the notion of compassionate technologies; discuss how contemporary paradigm shifts such as the inclusive design movement may be harnessed to build tools and platforms that promote collective good and increase prosocial behavior; and highlight examples of initiatives that are harnessing modern technology to advance democracy, collective knowledge, and personal freedoms and agency. (shrink)

Written in the 1960s, TRUTH AND METHOD is Gadamer's magnum opus. Looking behind the self-consciousness of science, he discusses the tense relationship between truth and methodology. In examining the different experiences of truth, he aims to "present the hermeneutic phenomenon in its fullest extent.

Since the publication of Wahrheit und Methode in 1960 (Tfibingen), Gadamer's hermeneutics has called forth a varied and fruitful response from the Continent, without receiving anything near the same attention from the English-speaking world. Though E. D. Hirsch thought Gadamer sufficiently important in 1965 to merit an early rebuttal and rehabilitation (Validity in Interpretation [New Haven, Conn., 1967], pp. 245-64), Wahrheit und Methode remained unread in England and America, partly because a translation was not available until 1975 (Truth and Method, (...) ed. Garrett Barden and John Cumming [New York]). Even after that date, Gadamer's influence on Anglo-American debate has been largely secondhand, filtering in through such figures as Paul Ricoeur and Jiurgen Habermas. But a renewed interest in the question of what we are to make of tradition, no doubt spurred in large measure by deconstruction's effort to unmake it, has lent Gadamer a new pertinence. One sign that his stock is on the rise is the publication of Joel Weinsheimer's Gadamer's Hermeneutics, a much needed and admirably written introduction to Truth and Method that should push its value even higher. -- JSTOR (June 12, 2012.). (shrink)

Jean Grondin’s starting point in his impressive book is what Hans-Georg Gadamer refers to as the universal claim of hermeneutics. Gadamer is better known for the limits his hermeneutics seems to place on universal claims. Against the reliance the Enlightenment placed on the insights of a reason common to humanity, Gadamer stresses the prejudiced and partial character of attempts to understand meaning. And against more contemporary attempts to ground Enlightenment conceptions in universal human competencies, he stresses the historicity and finitude (...) of human knowledge. Our attempts to understand the meaning of texts, conversations, historical events, and social actions and practices are conditioned by the horizon of our language, our own historical experiences, and our assumptions and expectations. Still, Gadamer ends his Truth and Method by stressing not only the linguistic character of understanding but the infinite capacity of all languages to find and express new dimensions of meaning. “Language,” he writes, “forestalls any objection to its jurisdiction. Its universality keeps pace with the universality of reason.”. (shrink)

In this lucid and elegantly written book, Joel Weinsheimer discusses how the insights of Hans-Georg Gadamer alter our understanding of literary theory and interpretation. Weinsheimer begins by surveying modern hermeneutics from Schleiermacher to Riocoeur, showing that Gadamer’s work is situated in the middle of an ongoing dialogue. Gadamer’s hermeneutics, says Weinsheimer, is specifically philosophical for it explores how understanding occurs at all, not how it should be regulated in order to function more rigorously or effectively. According (...) to Weinsheimer, Gadamer views understanding as an effect of history, not an action but a passion, something that happens to the interpreter. Gadamer offers a new model of historical understanding that is based on metaphor: it fuses the different into the same but, like metaphor, does not repress difference. Similarly, Gadamer’s critique of the semiotic conception of language redresses the balance between difference and sameness in the relation of word and world. The common thread in the contributions of philosophical hermeneutics to literary theory is the multifaceted tension between the one and the many, between sameness and difference. This appears in metaphor and application, in the complex dialogue between the past and present, and between the interpretation and the interpreted generally. In the final chapter of the book, “The Question of the Classic,” Weinsheimer explores the implications of this analysis of Gadamer’s hermeneutics for the current debate concerning the study of the canon and the classic. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Joel Weinsheimer HISTORY AND THE FUTURE OF MEANING In "meaning and Significance Reinterpreted," E. D. Hirsch, Jr. offers what he calls a "new and different theory" of meaning, one which radically reduces the role of the mens auctoris as the normative principle defining validity in literary interpretation.1 Clearly this essay marks a noteworthy shift in Hirsch's own thought, though in the history of hermeneutics such a reduction (...) is of itself hardly new. More interesting are the arguments Hirsch offers for this "correction" of his views, and in particular his thesis that in the process of application "responsible interpreters can adjust old concepts to new beliefs" and still say that they "have not really changed the text's meaning. They can properly say this, first of all, on grounds that... the original speech-intent subsumes new contents in the way that a concept subsumes examples, whether or not the examples were available to the original speaker. But in addition to this, the provisionality of speech sanctions a degree of adjustment in the original concepts as well" (p. 223). Application does not alter meaning if the new example can be subsumed under the original concept or if the original concept is itself originally provisional and adjustable. Thus Hirsch now concurs with Gadamer that application belongs to meaning and yet still dissents from Gadamer's thesis that application to situations unlike those the author envisioned necessarily changes the meaning. If determinacy of meaning is to be preserved, the essential question is, how far can sameness be unlike without becoming difference? Hirsch replies, "It appears... that meaning can tolerate a small revision in mental content and remain the same — but not a big revision.... In our ordinary talk about language, our judgment of sameness of meaning is based on our ad hoc judgment about the closeness of two contents" (p. 221). 139 140Philosophy and Literature Since I (and, I think, Gadamer) agree in great part with this conclusion, Hirsch's theory in my view does not need to be refuted and replaced with something new and different. Rather, in the spirit of his essay, I propose to adjust and build on it — by showing first that the development of Hirsch's argument rehearses Kant's movement from the first Critique to the third, second that the result of merging the two Critiques is unacceptable, and finally that Gadamer's reading of Kant anticipates and refines Hirsch's new theory while avoiding its unacceptable consequences. "The first amendment I must make in my original explanation of the distinction between meaning and significance is to reject my earlier claim that future applications of meaning, each being different, must belong to the domain of significance" (p. 210). In this first phase of his argument, Hirsch argues that the details of literary texts exemplify concepts that are themselves broader than the particulars that exemplify them. In Shakespeare 's sonnet 55, "marble" exemplifies what will last long but not forever. Just as the sonnet itself offers additional instances of this concept, so also the interpreter can find still other, more modern examples of it. Even if Shakespeare did not mention these modern examples and could not be said to have had them in mind, yet they too belong to the poem's self-same meaning if they can be subsumed under the original concept and thus belong to its extension. We can always find more examples, then, and in Hirsch's view this means that through its applications a poem can always become fresh again without altering its meaning. But here's the rub: if new instances are always to be found and thus no instance ever exhausts a concept, then no instance ever fully exemplifies a concept. Every example is a bad example, and Shakespeare would have done better to stick to conceptual language in the first place. If this conclusion is unacceptable, then we can reverse it. When the purpose is only to exemplify a concept, the difference between two examples (say, marble and steel) can be ignored as irrelevant. But it is nonetheless real. Certain elements of the particular example must be eliminated before it can be used to exemplify the general concept. But... (shrink)

In this book, first published in 1984, Joel Weinsheimer advocates revitalizing the practice of imitating literature as a mode appropriate for literary critics as well as artists. The book is not only about imitation; it is itself an imitation, specifically of Samuel Johnson. As both the focus and mode of presentation, imitation is presented not merely as a kind of poetry that once flourished in the eighteenth century but also as a kind of criticism particularly relevant today. Applying (...) arguments from philosophy of science, deconstruction, psycho-analysis, literary theory, semiotics and hermeneutics, Weinsheimer shows that the three main currents of thought responsible for forcing imitation underground were empiricism, originalism and historicism. The three central chapters of the book concentrate on their representatives: John Locke, Edward Young and Thomas Warton. The author then applies Johnsonian arguments – supported by those of Gadamer Peirce – to challenge those objections and re-establish imitation as an intellectually defensible mode of writing. (shrink)

In the years shortly before and after the publication of his classic _Truth and Method_, the eminent German philosopher Hans-Georg Gadamer returned often to questions surrounding religion and ethics. In this selection of writings from _Gesammelte Werke_ that are here translated into English for the first time, Gadamer probes deeply into the hermeneutic significance of these subjects. Gadamer raises issues of importance to ethicists and theologians as well as students of language and literature. In such outstanding essays as "Kant and (...) the Question of God," "Thinking as Redemption: Plotinus between Plato and Augustine," and "Friendship and Self-Knowledge: Reflections on the Role of Friendship in Greek Ethics," Gadamer discusses the nature of moral behavior, ethics as a form of knowing, and the hermeneutic task of mediating ethos and philosophical ethics with one another. (shrink)

In this wide-ranging historical introduction to philosophical hermeneutics, Jean Grondin discusses the major figures from Philo to Habermas, analyzes conflicts between various interpretive schools, and provides a persuasive critique of Gadamer's view of hermeneutic history, though in other ways Gadamer's _Truth and Method_ serves as a model for Grondin's approach. Grondin begins with brief overviews of the pre-nineteenth-century thinkers Philo, Origen, Augustine, Luther, Flacius, Dannhauer, Chladenius, Meier, Rambach, Ast, and Schlegel. Next he provides more extensive treatments of such major nineteenth-century (...) figures as Schleiermacher, Böckh, Droysen, and Dilthey. There are full chapters devoted to Heidegger and Gadamer as well as shorter discussions of Betti, Habermas, and Derrida. Because he is the first to pay close attention to pre-Romantic figures, Grondin is able to show that the history of hermeneutics cannot be viewed as a gradual, steady progression in the direction of complete universalization. His book makes it clear that even in the early period, hermeneutic thinkers acknowledged a universal aspect in interpretation—that long before Schleiermacher, hermeneutics was philosophical and not merely practical. In revising and correcting the standard account, Grondin's book is not merely introductory but revisionary, suitable for beginners as well as advanced students in the field. (shrink)

In the preface to the Yale edition of Samuel Johnson’s poems, the editors remark that “for a modern reader who can recreate the situation in which [“London”] was written, it may still be exciting enough. But to one with less imaginative capacity or historical knowledge, its appeal lies in Johnson’s skillful handling of the couplet.”2 To assist us in re-creating the milieu of 1738, the editors supply the usual notes identifying various historical personages and events which are no longer in (...) the domain of common knowledge. In this respect they follow Johnson’s lead. “London” is manifestly an occasional poem; and its occasion—in part, Walpole’s timidity abroad and corruption at home—like all occasions, passed.3 Indeed it passed so quickly that Johnson himself felt called upon in the fifth edition to annotate, for instance, his mention of “the Gazetteer”: “the paper which at that time contained apologies for the Court.” By 1750 Walpole was long out of court, the Gazetteer extinct, and “London” as outdated as yesterday’s newspaper.For poems like “London” whose contents are neither au courant nor immortal but rather historical or simply dead, the Yale editors suggest two avenues of resuscitation: the reader may either restore the background by means of historical imagination or, failing that, admire Johnson’s couplet art, which perhaps has a better chance at perennial appeal. Either content or form, either history or art—both options require a sacrifice on our part, and that sacrifice is our occasion, our need. Even assuming that the poem’s context could be exhumed and that we could participate once again in all the rage of the “patriot” opposition to Walpole, Why would we want to? The problem is that not only “London” but the Walpole regime itself is now defunct. Yet the same question must be asked of the poem’s art, even and especially if it is eternal. Why are we interested in the aesthetic knowledge of couplets that have been drained of all substance? Is understanding “London” in either case an end in itself? The pure content of the poem is too concrete, its pure form too abstract, to answer our occasions. Thus to understand the poem as either history or art demands a leisure that has no exigencies and is therefore free for the bygone and ethereal.42. E.L. McAdam, Jr. and George Milne, eds., Poems, vol. 6, The Yale Edition of the Works of Samuel Johnson , p. xvii.3. For a detailed exposition of the social and political background of “London,” see Donald Greene, The Politics of Samuel Johnson , pp. 88-92, and James Clifford, “London,” Young Sam Johnson , pp. 175-94.4. John Locke explains the infinite leisure we can take in understanding the obscurities of ancient authors in An Essay Concerning Human Understanding, ed. Alexander Campbell Fraser, 2 vols. , 2:110:There being no writings we have any great concernment to be very solicitous about the meaning of, but those that contain either truths we are required to believe, or laws we are to obey, and draw inconveniences on us when we mistake or transgress, we may be less anxious about the sense of other authors; who, writing but their own opinions, we are under no greater necessity to know them, than they to know ours. Our good or evil depending not on their decrees, we may safely be ignorant of their notions: and therefore in the reading of them, if they do not use their words with a due clearness and perspicuity, we may lay them aside. (shrink)